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Switching on a Nontraditional Enzymatic Base – Deprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum

Terpene synthases often catalyze complex carbocation cascade reactions. It has been previously shown that single residue switches involving replacement of a key aliphatic residue with serine or threonine can “short-circuit” such reactions, presumed to act indirectly via dipole stabilization of inter...

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Bibliografske podrobnosti
izdano v:ACS Catal
Main Authors: Jia, Meirong, Zhang, Yue, Siegel, Justin B., Tantillo, Dean J., Peters, Reuben J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266162/
https://ncbi.nlm.nih.gov/pubmed/32489716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b02783
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