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Repurposing propranolol as an antitumor agent in von Hippel-Lindau disease
OBJECTIVE: Von Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs...
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| Publicado no: | J Neurosurg |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7265978/ https://ncbi.nlm.nih.gov/pubmed/30497198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2018.5.JNS172879 |
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