Repurposing propranolol as an antitumor agent in von Hippel-Lindau disease

OBJECTIVE: Von Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs...

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Bibliografische gegevens
Gepubliceerd in:J Neurosurg
Hoofdauteurs: Shepard, Matthew J., Bugarini, Alejandro, Edwards, Nancy A., Lu, Jie, Zhang, Qi, Wu, Tianxia, Zhuang, Zhengping, Chittiboina, Prashant
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265978/
https://ncbi.nlm.nih.gov/pubmed/30497198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2018.5.JNS172879
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