Microenvironment-Derived FGF-2 Stimulates Renal Cell Carcinoma Cell Proliferation through Modulation of p27(Kip1): Implications for Spatial Niche Formation and Functional Intratumoral Heterogeneity

BACKGROUND/OBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is characterized by a high degree of functional intratumoral heterogeneity (ITH). This is highlighted by the finding that tumor cell proliferation and intracellular signaling occur preferentially in the tumor periphery. The driving forces...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Pathobiology
Päätekijät: Hou, Weibin, Kaczorowski, Adam, Lantwin, Philippa, Kippenberger, Maximilian, Schütz, Viktoria, Franke, Desiree, Dieffenbacher, Svenja Christina, Hohenfellner, Markus, Duensing, Stefan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: S. Karger AG 2020
Aiheet:
Original Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265770/
https://ncbi.nlm.nih.gov/pubmed/32229735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000506709
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