Microenvironment-Derived FGF-2 Stimulates Renal Cell Carcinoma Cell Proliferation through Modulation of p27(Kip1): Implications for Spatial Niche Formation and Functional Intratumoral Heterogeneity

BACKGROUND/OBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is characterized by a high degree of functional intratumoral heterogeneity (ITH). This is highlighted by the finding that tumor cell proliferation and intracellular signaling occur preferentially in the tumor periphery. The driving forces...

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Dettagli Bibliografici
Pubblicato in:Pathobiology
Autori principali: Hou, Weibin, Kaczorowski, Adam, Lantwin, Philippa, Kippenberger, Maximilian, Schütz, Viktoria, Franke, Desiree, Dieffenbacher, Svenja Christina, Hohenfellner, Markus, Duensing, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2020
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265770/
https://ncbi.nlm.nih.gov/pubmed/32229735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000506709
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