Leukemia Inhibitory Factor Signaling Enhances Production of Galactose-Deficient IgA1 in IgA Nephropathy

OBJECTIVES: IgA nephropathy (IgAN) is thought to involve an autoimmune process wherein galactose-deficient IgA1 (Gd-IgA1), recognized as autoantigen by autoantibodies, forms pathogenic immune complexes. Mounting evidence has implicated abnormal activation of some protein-tyrosine kinases (PTKs) in I...

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Udgivet i:Kidney Dis (Basel)
Main Authors: Yamada, Koshi, Huang, Zhi qiang, Raska, Milan, Reily, Colin, Anderson, Joshua C., Suzuki, Hitoshi, Kiryluk, Krzysztof, Gharavi, Ali G., Julian, Bruce A., Willey, Christopher D., Novak, Jan
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265702/
https://ncbi.nlm.nih.gov/pubmed/32523959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000505748
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