Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide...

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Pubblicato in:Kidney Int
Autori principali: Bajaj, Archna, Ihegword, Andrea, Qiu, Chengxiang, Small, Aeron M., Wei, Wei-Qi, Bastarache, Lisa, Feng, QiPing, Kember, Rachel L, Risman, Marjorie, Bloom, Roy D., Birtwell, David L., Williams, Heather, Shaffer, Christian M., Chen, Jinbo, Denny, Joshua C., Rader, Daniel J., Stein, C. Michael, Damrauer, Scott M., Susztak, Katalin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265573/
https://ncbi.nlm.nih.gov/pubmed/32247630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.01.027
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