Human norovirus targets enteroendocrine epithelial cells in the small intestine

Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Green, Kim Y., Kaufman, Stuart S., Nagata, Bianca M., Chaimongkol, Natthawan, Kim, Daniel Y., Levenson, Eric A., Tin, Christine M., Yardley, Allison Behrle, Johnson, Jordan A., Barletta, Ana Beatriz F., Khan, Khalid M., Yazigi, Nada A., Subramanian, Sukanya, Moturi, Sangeetha R., Fishbein, Thomas M., Moore, Ian N., Sosnovtsev, Stanislav V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265440/
https://ncbi.nlm.nih.gov/pubmed/32488028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16491-3
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