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Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors

The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N’s function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Wang, Yong, Zhan, Qi, Wang, Xinlu, Li, Peipei, Liu, Songqing, Gao, Guangxia, Gao, Pu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265302/
https://ncbi.nlm.nih.gov/pubmed/32488130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16587-w
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