Legionella pneumophila regulates the activity of UBE2N by deamidase‐mediated deubiquitination

The Legionella pneumophila effector MavC induces ubiquitination of the E2 ubiquitin‐conjugating enzyme UBE2N by transglutamination, thereby abolishing its function in the synthesis of K(63)‐type polyubiquitin chains. The inhibition of UBE2N activity creates a conundrum because this E2 enzyme is impo...

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Udgivet i:EMBO J
Main Authors: Gan, Ninghai, Guan, Hongxin, Huang, Yini, Yu, Ting, Fu, Jiaqi, Nakayasu, Ernesto S, Puvar, Kedar, Das, Chittaranjan, Wang, Dongmei, Ouyang, Songying, Luo, Zhao‐Qing
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024838/
https://ncbi.nlm.nih.gov/pubmed/31825121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102806
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