Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues

Many chaperones favour binding to hydrophobic sequences that are flanked by basic residues while disfavouring acidic residues. However, the origin of this bias in protein quality control remains poorly understood. Here, we show that while acidic residues are the most efficient aggregation inhibitors...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:EMBO J
Hlavní autoři: Houben, Bert, Michiels, Emiel, Ramakers, Meine, Konstantoulea, Katerina, Louros, Nikolaos, Verniers, Joffré, van der Kant, Rob, De Vleeschouwer, Matthias, Chicória, Nuno, Vanpoucke, Thomas, Gallardo, Rodrigo, Schymkowitz, Joost, Rousseau, Frederic
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265246/
https://ncbi.nlm.nih.gov/pubmed/32237079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102864
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky