Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues

Many chaperones favour binding to hydrophobic sequences that are flanked by basic residues while disfavouring acidic residues. However, the origin of this bias in protein quality control remains poorly understood. Here, we show that while acidic residues are the most efficient aggregation inhibitors...

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Udgivet i:EMBO J
Main Authors: Houben, Bert, Michiels, Emiel, Ramakers, Meine, Konstantoulea, Katerina, Louros, Nikolaos, Verniers, Joffré, van der Kant, Rob, De Vleeschouwer, Matthias, Chicória, Nuno, Vanpoucke, Thomas, Gallardo, Rodrigo, Schymkowitz, Joost, Rousseau, Frederic
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265246/
https://ncbi.nlm.nih.gov/pubmed/32237079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102864
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