Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues

Many chaperones favour binding to hydrophobic sequences that are flanked by basic residues while disfavouring acidic residues. However, the origin of this bias in protein quality control remains poorly understood. Here, we show that while acidic residues are the most efficient aggregation inhibitors...

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Publicat a:EMBO J
Autors principals: Houben, Bert, Michiels, Emiel, Ramakers, Meine, Konstantoulea, Katerina, Louros, Nikolaos, Verniers, Joffré, van der Kant, Rob, De Vleeschouwer, Matthias, Chicória, Nuno, Vanpoucke, Thomas, Gallardo, Rodrigo, Schymkowitz, Joost, Rousseau, Frederic
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265246/
https://ncbi.nlm.nih.gov/pubmed/32237079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102864
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