WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice

Hippo signaling acts as a tumor suppressor pathway by inhibiting the proliferation of adult stem cells and progenitor cells in various organs. Liver-specific deletion of Hippo pathway components in mice induces liver cancer development through activation of the transcriptional coactivators, YAP and...

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Pubblicato in:Mol Cells
Autori principali: Park, Jaeoh, Kim, Jeong Sik, Nahm, Ji Hae, Kim, Sang-Kyum, Lee, Da-Hye, Lim, Dae-Sik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Society for Molecular and Cellular Biology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264477/
https://ncbi.nlm.nih.gov/pubmed/32451369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2020.0093
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