Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Synthetic biology is a powerful tool to create therapeutics which can be rationally designed to enable unique and combinatorial functionalities. Here we utilize non-pathogenic E coli Nissle as a versatile platform for the development of a living biotherapeutic for the treatment of cancer. The engine...

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Vydáno v:Nat Commun
Hlavní autoři: Leventhal, Daniel S., Sokolovska, Anna, Li, Ning, Plescia, Christopher, Kolodziej, Starsha A., Gallant, Carey W., Christmas, Rudy, Gao, Jian-Rong, James, Michael J., Abin-Fuentes, Andres, Momin, Munira, Bergeron, Christopher, Fisher, Adam, Miller, Paul F., West, Kip A., Lora, Jose M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264239/
https://ncbi.nlm.nih.gov/pubmed/32483165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16602-0
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