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Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss

Hearing loss affects more than two-thirds of the elderly population, and more than 17% of all adults in the U.S. Sensorineural hearing loss related to noise exposure or aging is associated with loss of inner ear sensory hair cells (HCs), cochlear spiral ganglion neurons (SGNs), and ribbon synapses b...

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Vydáno v:Bioconjug Chem
Hlavní autoři: Kempfle, Judith S., Nguyen, Kim, Hamadani, Christine, Koen, Nicholas, Edge, Albert S., Kashemirov, Boris A., Jung, David H., McKenna, Charles E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263315/
https://ncbi.nlm.nih.gov/pubmed/29485861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00022
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