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CRISPR-Cas9-mediated pinpoint microbial genome editing aided by target-mismatched sgRNAs
Genome editing has been revolutionized by the CRISPR-Cas9 system. CRISPR-Cas9 is composed of single-molecular guide RNA (sgRNA) and a proteinaceous Cas9 nuclease, which recognizes a specific target sequence and a protospacer adjacent motif (PAM) sequence and, subsequently, cleaves the targeted DNA s...
Enregistré dans:
| Publié dans: | Genome Res |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7263196/ https://ncbi.nlm.nih.gov/pubmed/32327447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.257493.119 |
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