Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by recurrent mutations in genes encoding transcriptional, chromatin, and/or signaling regulators. The t(8;21) translocation generates the aberrant transcription factor RUNX1-ETO (RUNX1-RUNX1T1), which by itself is insufficient to caus...

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Foilsithe in:Cell Rep
Main Authors: Nafria, Monica, Keane, Peter, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Bonifer, Constanze
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Press 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262600/
https://ncbi.nlm.nih.gov/pubmed/32460028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107691
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