Direct High‐Throughput Screening Assay for mRNA Cap Guanine‐N7 Methyltransferase Activity

In eukaryotes, mature mRNA is formed through modifications of precursor mRNA, one of which is 5’ cap biosynthesis, involving RNA cap guanine‐N7 methyltransferase (N7‐MTase). N7‐MTases are also encoded by some eukaryotic viruses and facilitate their replication. N7‐MTase inhibitors have therapeutic p...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Kasprzyk, Renata, Fido, Mateusz, Mamot, Adam, Wanat, Przemyslaw, Smietanski, Miroslaw, Kopcial, Michal, Cowling, Victoria H., Kowalska, Joanna, Jemielity, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262028/
https://ncbi.nlm.nih.gov/pubmed/32259329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001036
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