Direct High‐Throughput Screening Assay for mRNA Cap Guanine‐N7 Methyltransferase Activity

In eukaryotes, mature mRNA is formed through modifications of precursor mRNA, one of which is 5’ cap biosynthesis, involving RNA cap guanine‐N7 methyltransferase (N7‐MTase). N7‐MTases are also encoded by some eukaryotic viruses and facilitate their replication. N7‐MTase inhibitors have therapeutic p...

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Publicat a:Chemistry
Autors principals: Kasprzyk, Renata, Fido, Mateusz, Mamot, Adam, Wanat, Przemyslaw, Smietanski, Miroslaw, Kopcial, Michal, Cowling, Victoria H., Kowalska, Joanna, Jemielity, Jacek
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Full Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262028/
https://ncbi.nlm.nih.gov/pubmed/32259329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001036
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