Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice

The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to obesity. However, in a commonly used model of T2D, the db/db mo...

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Gepubliceerd in:Mol Cell Proteomics
Hoofdauteurs: Kang, Taewook, Boland, Brandon B., Jensen, Pia, Alarcon, Cristina, Nawrocki, Arkadiusz, Grimsby, Joseph S., Rhodes, Christopher J., Larsen, Martin R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261816/
https://ncbi.nlm.nih.gov/pubmed/32265294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001882
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