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Cellular phosphatidic acid sensor, α-synuclein N-terminal domain, detects endogenous phosphatidic acid in macrophagic phagosomes and neuronal growth cones

Phosphatidic acid (PA) is the simplest phospholipid and is involved in the regulation of various cellular events. Recently, we developed a new PA sensor, the N-terminal region of α-synuclein (α-Syn-N). However, whether α-Syn-N can sense physiologically produced, endogenous PA remains unclear. We fir...

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Pubblicato in:Biochem Biophys Rep
Autori principali: Yamada, Haruka, Hoshino, Fumi, Lu, Qiang, Sakane, Fumio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261706/
https://ncbi.nlm.nih.gov/pubmed/32490215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100769
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