Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

Therapeutic resistance remains a persistent challenge for patients with malignant tumors. Here, we reveal that endothelial cells (ECs) acquire transformation into mesenchymal stem cell (MSC)–like cells in glioblastoma (GBM), driving tumor resistance to cytotoxic treatment. Transcriptome analysis by...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Huang, Menggui, Zhang, Duo, Wu, Janet Y., Xing, Kun, Yeo, Eujin, Li, Chunsheng, Zhang, Lin, Holland, Eric, Yao, Lutian, Qin, Ling, Binder, Zev A., O’Rourke, Donald M., Brem, Steven, Koumenis, Constantinos, Gong, Yanqing, Fan, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261487/
https://ncbi.nlm.nih.gov/pubmed/32102932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay7522
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