Unblending of transcriptional condensates in human repeat expansion disease

Expansion of amino acid repeats occurs in >20 inherited human disorders, and many occur in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are associated with protein aggregation, but the contribution of aggregates to pathology has been controversial. Here we...

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Publicado no:Cell
Main Authors: Basu, Shaon, Mackowiak, Sebastian D., Niskanen, Henri, Knezevic, Dora, Asimi, Vahid, Grosswendt, Stefanie, Geertsema, Hylkje, Ali, Salaheddine, Jerković, Ivana, Ewers, Helge, Mundlos, Stefan, Meissner, Alexander, Ibrahim, Daniel M., Hnisz, Denes
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261253/
https://ncbi.nlm.nih.gov/pubmed/32386547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.04.018
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