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TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related neurodegenerative diseases that present with similar TDP-43 pathology in patient tissue. TDP-43 is an RNA-binding protein which forms aggregates in neurons of ALS and FTD patients as well as in a subset of patients...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7260973/ https://ncbi.nlm.nih.gov/pubmed/32393629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917038117 |
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