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Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin

The intestinal mucosa exists in dynamic balance with trillions of luminal microbes. Disruption of the intestinal epithelial barrier, commonly observed in mucosal inflammation and diseases such as inflammatory bowel diseases (IBDs), is often associated with dysbiosis, particularly decreases in specie...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wang, Ruth X., Lee, J. Scott, Campbell, Eric L., Colgan, Sean P.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260972/
https://ncbi.nlm.nih.gov/pubmed/32398370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917597117
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