ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSCs are extremely plastic and can successfully adapt to targeted therapies. In this study, we...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Alcalá, Sonia, Sancho, Patricia, Martinelli, Paola, Navarro, Diego, Pedrero, Coral, Martín-Hijano, Laura, Valle, Sandra, Earl, Julie, Rodríguez-Serrano, Macarena, Ruiz-Cañas, Laura, Rojas, Katerin, Carrato, Alfredo, García-Bermejo, Laura, Fernández-Moreno, Miguel Ángel, Hermann, Patrick C., Sainz, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260233/
https://ncbi.nlm.nih.gov/pubmed/32472071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16395-2
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi