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OPRM1, OPRK1 and COMT Genetic Polymorphisms Associated with Opioid Effects on Experimental Pain: A Randomized, Double-Blind, Placebo-Controlled Study

Genetic polymorphisms have been shown to affect opioid requirement for pain relief. However, true genetic effect is often difficult to assess due to underlying pain conditions and placebo effects. The goal of this study was to understand how common polymorphisms affect opioid effects while controlli...

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Pubblicato in:Pharmacogenomics J
Autori principali: Ho, Kwo Wei David, Wallace, Margaret R., Staud, Roland, Fillingim, Roger B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260086/
https://ncbi.nlm.nih.gov/pubmed/31806881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-019-0131-z
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