Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt

Glioblastoma multiforme (GBM) contains a subpopulation of cells, GBM stem cells (GSCs), that maintain the bulk tumor and represent a key therapeutic target. Norrin is a Wnt ligand that binds Frizzled class receptor 4 (FZD4) to activate canonical Wnt signaling. Although Norrin, encoded by NDP, has a...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: El-Sehemy, Ahmed, Selvadurai, Hayden, Ortin-Martinez, Arturo, Pokrajac, Neno, Mamatjan, Yasin, Tachibana, Nobuhiko, Rowland, Katherine, Lee, Lilian, Park, Nicole, Aldape, Kenneth, Dirks, Peter, Wallace, Valerie A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260036/
https://ncbi.nlm.nih.gov/pubmed/32182224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128994
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