Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells

As treatment of the early, inflammatory phase of sepsis improves, post-sepsis immunosuppression and secondary infection have increased in importance. How early inflammation drives immunosuppression remains unclear. Although IFN-γ typically helps microbial clearance, we found that increased plasma IF...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Kim, Edy Y., Ner-Gaon, Hadas, Varon, Jack, Cullen, Aidan M., Guo, Jingyu, Choi, Jiyoung, Barragan-Bradford, Diana, Higuera, Angelica, Pinilla-Vera, Mayra, Short, Samuel A.P., Arciniegas-Rubio, Antonio, Tamura, Tomoyoshi, Leaf, David E., Baron, Rebecca M., Shay, Tal, Brenner, Michael B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260006/
https://ncbi.nlm.nih.gov/pubmed/32154791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128075
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