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CCL5 mediates CD40-driven CD4(+) T cell tumor infiltration and immunity

The role CD4(+) T cells play in tumor immunity is less well appreciated than the cytotoxic role of CD8(+) T cells. Despite clear evidence for CD4(+) T cell dependency across multiple immunotherapies, the mechanisms by which CD4(+) T cells infiltrate tumors remain poorly understood. Prior studies by...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Huffman, Austin P., Lin, Jeffrey H., Kim, Samuel I., Byrne, Katelyn T., Vonderheide, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259512/
https://ncbi.nlm.nih.gov/pubmed/32324594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137263
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