Soyasaponin A1 Inhibits the Lipid Raft Recruitment and Dimerization of TLR4, MyD88 and TRIF in Palmitate-Stimulated Inflammatory Macrophages

OBJECTIVES: Soyasaponin A(1) (SS(A1)) was previously shown to inhibit the palmitate (PA)-induced inflammation via regulating the toll-like receptor 4 (TLR4) signaling in macrophages. Since the lipid raft recruitment and dimerization of TLR4 and its downstream adaptor molecules are vital for PA-initi...

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Vydáno v:Curr Dev Nutr
Hlavní autoři: Gu, Xiangfu, Chen, Junbin, Zheng, Zhongdaixi, Xiao, Lingyu, Su, Chuhong, Xiong, Fei, Zha, Longying
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Nutritional Immunology and Inflammation/Immunometabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259113/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzaa068_007
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