Loss of Histone Deacetylase 4 in Hepatocytes Increases De Novo Lipogenesis in Diet-Induced Obesity Mice

OBJECTIVES: Evidence suggests that histone deacetylase 4 (HDAC4) is downregulated in adipose tissue of obese subjects. We determined the role of HDAC4 in the regulation of energy metabolism of metabolically active tissues, such as the liver and adipose tissue. METHODS: Hepatocyte-specific (Hdac4(HKO...

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Detalhes bibliográficos
Publicado no:Curr Dev Nutr
Main Authors: Lee, Yoojin, Bae, Minkyung, Chamberlain, Dana, Pham, Tho, Kang, Hyunju, Kim, Mi-Bo, Hu, Siqi, Park, Young-Ki, Lee, Ji-Young
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Obesity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7258917/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzaa063_050
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