Apolipoprotein E Genotype-Dependent Nutrigenetic Effects to Prebiotic Inulin for Reducing Risk for Alzheimer's Disease in a Mouse Model

OBJECTIVES: Apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD). Cognitively normal APOE4 carriers show an early decline in brain metabolic functions and gut microbiome dysbiosis before the onset of AD compared to APOE3 carriers. Our laboratory p...

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Detalhes bibliográficos
Publicado no:Curr Dev Nutr
Main Authors: Chang, Ya-Hsuan, Hoffman, Jared, Yanckello, Lucille, McCulloch, Scott, Lin, Penghui, Lane, Andrew, Chlipala, George, Green, Stefan, Lin, Ai-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Neuroscience, Nutrition and the Brain
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7258715/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzaa057_013
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