Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice

Cisplatin is a highly effective chemotherapeutic agent. However, its use is limited by nephrotoxicity. Enalapril is an angiotensin I-converting enzyme inhibitor used for the treatment of hypertension, mainly through the reduction of angiotensin II formation, but also through the increase of kinins h...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Estrela, Gabriel R., Wasinski, Frederick, Gregnani, Marcos F., Freitas-Lima, Leandro C., Arruda, Adriano C., Morais, Rafael Leite, Malheiros, Denise MAC, Camara, Niels O. S., Pesquero, João Bosco, Bader, Michael, Barros, Carlos Castilho, Araújo, Ronaldo Carvalho
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7257977/
https://ncbi.nlm.nih.gov/pubmed/32528973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00096
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