PPAR-α Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2

Cisplatin is a chemotherapy drug widely used in the treatment of solid tumors. However, nephrotoxicity has been reported in about one-third of patients undergoing cisplatin therapy. Proximal tubules are the main target of cisplatin toxicity and cellular uptake; elimination of this drug can modulate...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Freitas-Lima, Leandro Ceotto, Budu, Alexandre, Arruda, Adriano Cleis, Perilhão, Mauro Sérgio, Barrera-Chimal, Jonatan, Araujo, Ronaldo Carvalho, Estrela, Gabriel Rufino
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582648/
https://ncbi.nlm.nih.gov/pubmed/33049997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197416
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