Dietary β-Hydroxy-β-Methylbutyrate Supplementation Promotes PDAC Response to Gemcitabine and Immunotherapy Response in Obese Mice

OBJECTIVES: Late diagnosis, aggressive underlying biology, and limited treatment options contribute towards the exceptionally poor survival of pancreatic ductal adenocarcinoma (PDAC). Obesity promotes both incidence and progression of PDAC via chronic systemic inflammation, generation of an immunosu...

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Опубликовано в: :Curr Dev Nutr
Главные авторы: Coleman, Michael, Liu, Kristyn, Tang, Xiaohu, Lashinger, Laura, Cui, Zhengrong, Hursting, Stephen
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Diet and Cancer
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7257762/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzaa044_012
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