SUPPRESSING MITOCHONDRIAL RESPIRATION IS CRITICAL FOR HYPOXIA TOLERANCE IN THE FETAL GROWTH PLATE

Oxygen (O(2)) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1α (Hif1a), a mediator of the cellular adaptation to low O(2) tension (hypoxia). Hypoxic cells require Hif1a to survive. Additionally, Hif1a is an inhibitor of mi...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Yao, Angela Qing, Khan, Mohd Parvez, Merceron, Christophe, LaGory, Edward L., Tata, Zachary, Mangiavini, Laura, Hu, Jiarui, Vemulapalli, Krishna, Chandel, Navdeep S., Giaccia, Amato J., Schipani, Ernestina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255488/
https://ncbi.nlm.nih.gov/pubmed/31105007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.029
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