EGFR targeting enhances the efficiency of chemotherapy through inhibiting IRE1α-XBP1s pathway in colorectal cancer cells

Targeting EGFR combined with chemotherapy is one of the most valuable therapeutic strategies in colorectal cancer. However, resistance remains a major obstacle to improve efficacy. IRE1α-XBP1s signaling pathway is activated in many malignant tumors, and plays important roles in chemoresistance. Ther...

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Detalhes bibliográficos
Publicado no:J Cancer
Main Authors: Huo, Miaomiao, Zhao, Yahui, Liu, Xianghe, Gao, Yang, Zhang, Die, Chang, Mengjiao, Liu, Mei, Xu, Ningzhi, Zhu, Hongxia
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255363/
https://ncbi.nlm.nih.gov/pubmed/32489465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.44234
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