Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma

A TLR9 agonist in combination with a PD-1 inhibitor produced powerful antitumor responses in a clinical trial despite TLR9 agonists as monotherapies failing to generate systemic antitumor immune responses due to immunosuppressive effects. However, the mechanism involved in the improved response indu...

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Publicado en:Theranostics
Autores principales: Zhou, Binghai, Yan, Jiuliang, Guo, Lei, Zhang, Bo, Liu, Shuang, Yu, Mincheng, Chen, Zheng, Zhang, Kewei, Zhang, Wentao, Li, Xiaoqiang, Xu, Yongfeng, Xiao, Yongsheng, Zhou, Jian, Fan, Jia, Hung, Mien-Chie, Li, Hui, Ye, Qinghai
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255037/
https://ncbi.nlm.nih.gov/pubmed/32483468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.44417
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