Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps

BACKGROUND: Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression of MUC5AC, the major macro-molecular constituent of airway mucus, the precise m...

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Veröffentlicht in:Allergy Asthma Clin Immunol
Hauptverfasser: Jiao, Jian, Zhang, Tao, Zhang, Yu, Li, Jingyun, Wang, Min, Wang, Ming, Li, Ying, Wang, Xiangdong, Zhang, Luo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254766/
https://ncbi.nlm.nih.gov/pubmed/32514271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13223-020-00440-2
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