Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10

BACKGROUND: Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8(+) T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15). Several preclinical models support the antitumo...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Bergamaschi, Cristina, Pandit, Hrishikesh, Nagy, Bethany A, Stellas, Dimitris, Jensen, Shawn M, Bear, Jenifer, Cam, Maggie, Valentin, Antonio, Fox, Bernard A, Felber, Barbara K, Pavlakis, George N
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254133/
https://ncbi.nlm.nih.gov/pubmed/32461349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000599
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