Monomeric NADH-Oxidizing Methylenetetrahydrofolate Reductases from Mycobacterium smegmatis Lack Flavin Coenzyme

5,10-Methylenetetrahydrofolate reductase (MetF/MTHFR) is an essential enzyme in one-carbon metabolism for de novo biosynthesis of methionine. Our in vivo and in vitro analyses of MSMEG_6664/MSMEI_6484, annotated as putative MTHFR in Mycobacterium smegmatis, failed to reveal their function as MTHFRs....

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Vydáno v:J Bacteriol
Hlavní autoři: Sah, Shivjee, Lahry, Kuldeep, Talwar, Chandana, Singh, Sudhir, Varshney, Umesh
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253612/
https://ncbi.nlm.nih.gov/pubmed/32253341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00709-19
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