Rapid formylation of the cellular initiator tRNA population makes a crucial contribution to its exclusive participation at the step of initiation

Initiator tRNAs (i-tRNAs) possess highly conserved three consecutive GC base pairs (GC/GC/GC, 3GC pairs) in their anticodon stems. Additionally, in bacteria and eukaryotic organelles, the amino acid attached to i-tRNA is formylated by Fmt to facilitate its targeting to 30S ribosomes. Mutations in GC...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Shah, Riyaz Ahmad, Varada, Rajagopal, Sah, Shivjee, Shetty, Sunil, Lahry, Kuldeep, Singh, Sudhir, Varshney, Umesh
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393288/
https://ncbi.nlm.nih.gov/pubmed/30608556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1310
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