Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells

WRN mutation causes a premature aging disease called Werner syndrome (WS). However, the mechanism by which WRN loss leads to progeroid features evident with impaired tissue repair and regeneration remains unclear. To determine this mechanism, we performed gene editing in reprogrammed induced pluripo...

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Bibliografische gegevens
Gepubliceerd in:Aging Cell
Hoofdauteurs: Tu, Jiajie, Wan, Chao, Zhang, Fengjie, Cao, Lianbao, Law, Patrick Wai Nok, Tian, Yuyao, Lu, Gang, Rennert, Owen M., Chan, Wai‐Yee, Cheung, Hoi‐Hung
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Original Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253065/
https://ncbi.nlm.nih.gov/pubmed/32320127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13116
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