Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells

WRN mutation causes a premature aging disease called Werner syndrome (WS). However, the mechanism by which WRN loss leads to progeroid features evident with impaired tissue repair and regeneration remains unclear. To determine this mechanism, we performed gene editing in reprogrammed induced pluripo...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Tu, Jiajie, Wan, Chao, Zhang, Fengjie, Cao, Lianbao, Law, Patrick Wai Nok, Tian, Yuyao, Lu, Gang, Rennert, Owen M., Chan, Wai‐Yee, Cheung, Hoi‐Hung
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253065/
https://ncbi.nlm.nih.gov/pubmed/32320127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13116
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