Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells

WRN mutation causes a premature aging disease called Werner syndrome (WS). However, the mechanism by which WRN loss leads to progeroid features evident with impaired tissue repair and regeneration remains unclear. To determine this mechanism, we performed gene editing in reprogrammed induced pluripo...

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Publicat a:Aging Cell
Autors principals: Tu, Jiajie, Wan, Chao, Zhang, Fengjie, Cao, Lianbao, Law, Patrick Wai Nok, Tian, Yuyao, Lu, Gang, Rennert, Owen M., Chan, Wai‐Yee, Cheung, Hoi‐Hung
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253065/
https://ncbi.nlm.nih.gov/pubmed/32320127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13116
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