Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells

WRN mutation causes a premature aging disease called Werner syndrome (WS). However, the mechanism by which WRN loss leads to progeroid features evident with impaired tissue repair and regeneration remains unclear. To determine this mechanism, we performed gene editing in reprogrammed induced pluripo...

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Vydáno v:Aging Cell
Hlavní autoři: Tu, Jiajie, Wan, Chao, Zhang, Fengjie, Cao, Lianbao, Law, Patrick Wai Nok, Tian, Yuyao, Lu, Gang, Rennert, Owen M., Chan, Wai‐Yee, Cheung, Hoi‐Hung
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Original Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253065/
https://ncbi.nlm.nih.gov/pubmed/32320127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13116
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