Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD8(+) T-cell responses

Patients with chronic lymphocytic leukemia (CLL) are characterized by monoclonal expansion of CD5(+)CD23(+)CD27(+)CD19(+)κ/λ(+) B lymphocytes and are clinically noted to have profound immune suppression. In these patients, it has been recently shown that a subset of B cells possesses regulatory func...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: Manna, Alak, Kellett, Timothy, Aulakh, Sonikpreet, Lewis-Tuffin, Laura J., Dutta, Navnita, Knutson, Keith, Chini, Eduardo, Pinilla-Ibarz, Javier, Lamanna, Nicole, Manochakian, Rami, Malavasi, Fabio, Sher, Taimur, Chanan-Khan, Asher A., Ailawadhi, Sikander, Paulus, Aneel
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2020
Assuntos:
Immunobiology and Immunotherapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252547/
https://ncbi.nlm.nih.gov/pubmed/32421811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001091
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