Cardioprotective effects of pharmacological blockade of the mitochondrial calcium uniporter on myocardial ischemia-reperfusion injury

PURPOSE: To evaluate whether the attenuation of mitochondrial Ca(2+) overload produced by pharmacological blockade of mitochondrial Ca(2+) uniporter (MCU) protects the myocardium against injuries caused by cardiac ischemia and reperfusion (CIR). METHODS: CIR was induced in adult male Wistar rats (30...

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Veröffentlicht in:Acta Cir Bras
Hauptverfasser: Menezes-Rodrigues, Francisco Sandro, Tavares, José Gustavo Padrão, Vasques, Enio Rodrigues, Errante, Paolo Ruggero, de Araújo, Erisvaldo Amarante, Pires-Oliveira, Marcelo, Scorza, Carla Alessandra, Scorza, Fúlvio Alexandre, Taha, Murched Omar, Caricati-Neto, Afonso
Format: Artigo
Sprache:Inglês
Veröffentlicht: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251977/
https://ncbi.nlm.nih.gov/pubmed/32692797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/s0102-865020200030000006
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