CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy

Innate immune activation is a major contributor to Alzheimer's Disease (AD) pathophysiology, although the mechanisms involved are poorly understood. Chemokine C-C motif ligand (CCL) 2 is produced by neurons and glial cells and is upregulated in the AD brain. Transgene expression of CCL2 in mous...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Joly-Amado, Aurelie, Hunter, Jordan, Quadri, Zainuddin, Zamudio, Frank, Rocha-Rangel, Patricia V., Chan, Deanna, Kesarwani, Anisha, Nash, Kevin, Lee, Daniel C., Morgan, Dave, Gordon, Marcia N., Selenica, Maj-Linda B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251073/
https://ncbi.nlm.nih.gov/pubmed/32508844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00997
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