Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis

Infection of mice with Rift Valley fever virus (RVFV) reproduces major pathological features of severe human disease, notably the early-onset hepatitis and delayed-onset encephalitis. We previously reported that the Rvfs2 locus from the susceptible MBT/Pas strain reduces survival time after RVFV inf...

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Published in:Sci Rep
Main Authors: Batista, Leandro, Jouvion, Gregory, Simon-Chazottes, Dominique, Houzelstein, Denis, Burlen-Defranoux, Odile, Boissière, Magali, Tokuda, Satoko, do Valle, Tania Zaverucha, Cumano, Ana, Flamand, Marie, Montagutelli, Xavier, Panthier, Jean-Jacques
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250886/
https://ncbi.nlm.nih.gov/pubmed/32457349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65683-w
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