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Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo

PURPOSE: The aim of the present study was to investigate the interactions of the main components of Lygodium root (ie, p-coumaric acid, acacetin, apigenin, buddleoside and Diosmetin-7-O-β-D-glucopyranoside) with cytochrome P450 3A enzyme activity both in vitro and in vivo. METHODS: In vitro inhibiti...

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Publicat a:Drug Des Devel Ther
Autors principals: Zhou, Yunfang, Hua, Ailian, Zhou, Quan, Geng, Peiwu, Chen, Feifei, Yan, Lianhe, Wang, Shuanghu, Wen, Congcong
Format: Artigo
Idioma:Inglês
Publicat: Dove 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250706/
https://ncbi.nlm.nih.gov/pubmed/32546958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S249308
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