Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In Vivo

The two known isoforms of IL-15 contain either a long signal peptide (LSP) or a short signal peptide (SSP), and are produced by alternatively spliced transcripts. It has been proposed that SSP IL-15 remains exclusively intracellular, and its function is unclear. In this study, we show that, similar...

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Pubblicato in:J Immunol
Autori principali: Bergamaschi, Cristina, Jalah, Rashmi, Kulkarni, Viraj, Rosati, Margherita, Zhang, Gen-Mu, Alicea, Candido, Zolotukhin, Andrei S., Felber, Barbara K., Pavlakis, George N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250482/
https://ncbi.nlm.nih.gov/pubmed/19696432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900693
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